Les Olympiens lost their crunch clash with Lens last time out, while Angers suffered their fourth-straight defeat at home to top-four hopefuls Monaco.
Marseille's eight-game unbeaten run came to an unwanted end last weekend after they lost 2-1 at Stade Bollaert-Delelis against Lens - a result which allowed Franck Haise's men to leapfrog them into second.
Goals from Seko Fofana and Lois Openda put the hosts into a commanding lead after 60 minutes, and despite a late strike from Dimitri Payet, the visitors were unable to prevent their first defeat since late February.
Igor Tudor's side sit third in the Ligue 1 standings with a quartet of matches left to play, two points behind Les Sang et Or and eights points behind league leaders Paris Saint-Germain.
Former Arsenal and Manchester United man Alexis Sanchez has found a loving home in the south of France this season, with the 34-year-old Chilean scoring 13 times in the league to date - his highest tally since his 2016-17 campaign at the Emirates.
Marseille have an impressive recent record against Angers on home soil, with Les Olympiens' last defeat on familiar territory versus Sunday's opponents coming all the way back in September 2015.