Fighting for their lives at the bottom end of the Bundesliga table, Schalke are bidding for a third victory on the spin, while Bayern remain one point clear of Borussia Dortmund at the summit.
It would not be unfair to say that Thomas Tuchel has experienced an indifferent start to his reign as Bayern Munich manager, as the new boss has overseen four wins, two draws and three losses since replacing Julian Nagelsmann in the Allianz Arena hot seat.
Still, the Bavarians find themselves in a familiar position with three matches remaining, with the perennial Bundesliga champions in pole position to clinch an 11th successive title and continue their hegemony over German football.
After suffering a shock 3-1 defeat to Tuchel's former club Mainz 05, Bayern bounced back with a routine 2-0 victory over Hertha Berlin before defeating Werder Bremen 2-1 last time out, courtesy of second-half goals from Serge Gnabry and Leroy Sane.
Despite all the change at the club in recent times, Bayern have remained consistent on home soil, winning 10 and drawing five of their 15 Bundesliga home games to stay unbeaten at the Allianz Arena this season.
Having won five of their previous six home league matches – scoring 18 goals in the process – Bayern Munich will be confident of dispatching relegation-threatened Schalke and strengthening their bid for yet another Bundesliga crown.