While the hosts are battling for Champions League qualification, the visitors need nothing short of a miracle to avoid relegation from the top flight.
AC Milan extended their unbeaten run in all competitions to seven matches after playing out a 1-1 draw away against Roma last weekend – their third draw by that scoreline in their last four games.
The contest in the Italian capital was goalless heading into stoppage time until Tammy Abraham netted what appeared to be a 94th-minute winner for the hosts, only for Alexis Saelemaekers to go up the other end three minutes later to score a dramatic equaliser and rescue a point for the visitors at the death.
Stefano Pioli's side, who are on the cusp of handing over their Scudetto title to Napoli, have slipped out of the top four and down to fifth place in the table, albeit on goal difference after rivals Inter secured a 3-1 win over second-placed Lazio.
Milan are now preparing for three successive home matches to begin the month of May, with back-to-back Serie A home encounters with Cremonese and Lazio followed by the first leg of the Champions League semi-final with bitter rivals Inter in a weeks' time.
The Rossoneri have put together a seven-game unbeaten run at San Siro, keeping six clean sheets in the process, and they will be hoping to have more joy in front of their own fans on Wednesday against a Cremonese side whom they thrashed 7-1 in their last top-flight home meeting back in May 1996.