The Groupama Stadium plays host to the 122nd Choc des Olympiques on Sunday evening, as Lyon lock horns with Marseille in the weekend's headline encounter.
Les Gones ran out 2-1 winners over Toulouse in their most recent fixture, while Igor Tudor's side also came up trumps in gameweek 31 - overcoming Troyes 3-1.
Barring a dampening Coupe de France semi-final exit to Nantes, the Lyon ship has been well and truly steadied under Laurent Blanc in 2023, and Les Gones are in with an outside chance of returning to European competition as the campaign draws to a close.
In what could have been a dress rehearsal for the domestic cup final, Alexandre Lacazette crashed home from the spot against Toulouse for his 19th goal of the campaign before Zakaria Aboukhlal levelled for Les Violets, only for the hapless Logan Costa to turn into his own net under pressure from Lacazette in the 88th minute.
Victory on Toulouse's turf extended Lyon's winning run in the top flight to three matches - as well as stretching their unbeaten streak to seven Ligue 1 games - and Blanc's side have suddenly surged up to seventh place in the table, five points worse off than Lille in the final continental spot.
Tightening up at the back has not exactly been the secret to Lyon's revival, as Blanc's men have just two clean sheets to show from their last 10 top-flight matches, but they have also failed to score just once in that sequence - a goalless stalemate with Lorient in early March.
However, victories at the Groupama Stadium have still been hard to come by for Lyon, who have prevailed in just three of their last 11 top-flight games in front of their own fans, but Marseille's recent trips to the Auvergne-Rhone-Alpes region have yielded little success.